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Safety and Side Effects While generally well-tolerated, there are some common side effects of GLP-1 agonists

placebo and dulaglutide, while only small differences between tirzepatide and placebo in terms of total cholesterol concentration and no changes in HDL and LDL cholesterol were detected [79]

Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase

The most common side effects reported in trials include: Digestive issues Nausea (the most frequently reported side effect) Vomiting Diarrhoea Constipation Stomach pain or discomfort Loss of appetite Other reported effects Fatigue or tiredness Injection site reactions (redness, swelling, or irritation) Most side effects tend to be worse when starting the medication or increasing the dose, and often improve as your body adjusts

Uncommon but Serious Side Effects While less common, these side effects may be more severe and require immediate medical attention

3B), along with a slightly increased expression of AHCY (Fig