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Other putative origins investigated in large, population-based datasets include chronic autoimmune syndromes such as inflammatory bowel disease and psoriasis [136, 137], and even after thermal injury, especially in extensive injuries and on sun-exposed body parts [138]
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Melasma is driven by ongoing hormonal triggers (estrogen, progesterone) and cumulative UV exposure that continuously stimulate melanocytes these triggers do not stop because a treatment course ends
In some cases, epitalon appeared to reduce tumor incidence in animal models
doi: 10.1002/2211-5463.13762 151 FrettsAMHazenSLJensenPBudoffMSitlaniCMWangMet al
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