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In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, digoxin, warfarin, or an oral contraception (ethinyl estradiol and norethindrone) (Table 5), providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, P-gp, and organic cationic transporter (OCT)

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In Locusta migratoria , LmGSTE4 was found to metabolize malathion and DDT

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Also tell them if you smoke, drink alcohol, or use illegal drugs

BPC-157 is considered safe for use, being naturally found in gastric juices (6)