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Vomiting, diarrhoea, and constipation occur with varying frequency, often correlating with dose escalation speed and individual sensitivity

A smaller number are genuine red flags that need same-day medical attention: acute pancreatitis, gallbladder disease, severe allergic reactions, acute kidney injury from dehydration, NAION (a rare vision disorder), and in people with Type 2 diabetes, hypoglycemia when combined with insulin or a sulfonylurea

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Environ Health Perspect 117(12):A535

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