While physiological ROS levels regulate adaptive pathways via Nrf2 and AMPK/PGC-1 signaling, excessive ROS become deleterious (Zhang et al., 2019)
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200,399,400,401,402 Elevated NNMT inhibits the methylation potential of cancer cells through inducing methyl sink in the form of MNA
The gene spans approximately 55.7 kb across 8 exons and codes for a protein in the NNMT/PNMT/TEMT family (EC 2.1.1.1)