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We first probed for sAC expression by immunoblotting and detected abundant protein expression in mouse hearts and specific heart chambers (Figure 2A)

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Current therapies under investigation (Table 8) are targeting muscle-specific kinase (MuSK), which promotes post-synaptic clustering, synaptogenesis via F-actin branching and dendritic proliferation [293], and reduction of aberrant sphingolipid regulation to promote NMJ stability [294]

It aligns with one full spermatogenesis cycle