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For people with healthy digestive systems, high-dose oral B12 supplements can be effective for a mild deficiency

Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial

K., Renninger NS, Newman

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However, vitamin B12 injections have not been proven to increase energy or promote weight loss in individuals who do not have a deficiency