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Effective for obesity regardless of diabetes status

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16 Berenbaum hypothesized that the therapeutic potential of GLP-1 in OA may arise from targeting the crosstalk between macrophages and fibroblasts, which are known to drive inflammation, fibrosis, and downstream cartilage damage

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In patients with established ASCVD, clinicians should consider using GLP-1RAs or SGLT2is with proven CVD benefit, independent of baseline HbA 1c , individualized A1C target, or metformin use [15, 17]

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