long term effects of glp 1 drugs From nausea and exhaustion to emotional shifts and social awkwardness, people on GLP-1 medications are sharing the side they didn't expect — and rarely see talked about. https://www.buzzfeed.com/victoriavouloumanos/ozempic-wegovy-mounjaro-glp-1 what are the long term

Biol Psychiatry 2008, 64(5):361368

Astroglial degeneration and death (Clasmatodendrosis) Many neuropathologies, including for example traumatic lesions, stroke or age-dependent diseases are associated with direct damage of astrocytes, causing their degeneration and death

Epigenomics (2017) 9(4):44761

CV outcomes for adult patients with type 2 diabetes and established cardiovascular disease LEADERa landmark CVOT for Victoza 1 9,340 patients Key inclusion criteria: T2D, A1C 7.0% Age 50 years and established CVD OR Age 60 years and risk factors for CVD Cardiovascular standards of care (antihypertensives, lipid-lowering agents, and antiplatelet therapy) Diabetes standards of care (lifestyle modification, OADs, and insulin) Duration 3.5-5 years Time to first major adverse cardiovascular event (MACE) composed of: Composite primary endpoint CV death Nonfatal MI Nonfatal stroke Prospectively designed and powered to assess noninferiority and then superiority Patients were titrated to maximum tolerated dose of 0.6 mg to 1.8 mg Median daily dose of Victoza was 1.78 mg Victoza significantly reduced MACE in adults with T2D and established CVD 1 Absolute risk reduction: 1.9% Median time of exposure to treatment: 3.5 years

Alharbi, R

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