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Eur J Med Res 29:205

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Within the research community, NNMT inhibition is studied in pre-clinical models for its relationship to the NAD+ salvage pathway, methyl-donor homeostasis, and adipocyte energy metabolism

Senescent chondrocytes have a senescence-associated secretory phenotype (SASP) and release harmful pro-inflammatory cytokines (e.g., IL-1, IL-6, and TNF-) and proteases into the cartilage microenvironment that degrade the extracellular matrix [11,12,13]

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