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Among GLP-1s, semaglutide demonstrated the strongest benefits, including ~ 40% lower depression-related outcomes and a 42% reduction in psychiatric hospitalization
Free from yeast, wheat, milk, eggs, soy, gelatin, peanuts, shellfish, and artificial additives
To lower the risk of side effects (or to relieve those that may appear), start with a small application and increase gradually over time
The liver enzyme pattern is noteworthy because retatrutide simultaneously shows potent fat-clearing effects in the liver (beneficial for MASLD/NAFLD) while occasionally triggering transient enzyme elevations
But the evidence supporting their effectiveness compared to injectable formulations remains limited
Citation: Wang T, Gou Z, Wang F, Ma M, Zhai S-d (2014) Comparison of GLP-1 Analogues versus Sitagliptin in the Management of Type 2 Diabetes: Systematic Review and Meta-Analysis of Head-to-Head Studies
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