Because fasted-state absorption allows the peptide to bind NNMT enzymes without interference from competing substrates in the gut
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Masnec S, Kokot A, Zlatar M, Kalauz M, Kunjko K, Radic B, et al
pre- and post-operative treatment, when requirements are increased as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders interfering with intake or absorption of vitamins, prolonged or wasting diseases, alcoholism and where other deficiencies exist
However, due to the complex web of factors that influence BAC levels, these methods can only be used as educated guesses
The frustration is real, and the science is finally catching up to it