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N Engl J Med 380:347357 Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, Masiukiewicz U, Charbonnel B, Frederich R, Gallo S, Cosentino F, Shih WJ, Gantz I, Terra SG, Cherney DZI, McGuire DK (2020) VERTIS CV Investigators

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In the context of statin research, their antitumor effects can be attributed to the disruption of protein prenylation, reduction of cholesterol levels, modulation of autophagy, promotion of ferroptosis in tumor cells, and inhibition of their proliferation and invasion[178]

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Disclaimer: The research regarding the synergistic preservation of pancreatic beta-cell function and the long-term impact on preventing systemic macrovascular damage is currently in the investigational or observational registry phase and is not yet standard clinical practice beyond established glycemic management for T2D