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This is based on the role of SAM as both an allosteric activator of cystathionine -synthase and an allosteric inhibitor of MTHFR, the enzyme that produces 5-methyltetrahydrofolate (Figure 2)

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J Biol Chem 290:1715417162 Zhu X, Kaverina I (2013) Golgi as an MTOC: making microtubules for its own good

B12 is generally safe when used under medical supervision

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