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In addition to the rapid epigenetic modulation of glutamatergic function, preclinical studies showed that boosting mitochondrial metabolism of LAC protects against oxidative stress, rapidly ameliorates insulin resistance, and reduces neuroinflammation by decreasing proinflammatory pathways such as NFkB in hippocampal and cortical neurons
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Physical inactivity, by contrast, promotes mitochondrial stagnation, impaired fatty acid oxidation, and chronic oxidative stress, further depleting glutathione reserves
Like other polyphenols, it is easily oxidized in aqueous solutions unless adequate precautions, acid pH, and absence of oxidants, are taken
