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At the metabolic level, dysbiosis can disrupt bile acid metabolism by increasing hydrophobic toxic bile acids while suppressing intestinal FXR signaling and fibroblast growth factor 19 (FGF19) expression, thereby relieving the negative feedback inhibition of hepatic cholesterol 7-hydroxylase (CYP7A1) and promoting bile acid pool expansion and hepatocellular lipotoxicity [285, 286]

Evaluation of combining kava extract with hormone replacement therapy in the treatment of postmenopausal anxiety

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