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So I called up a co-author of the study, the Washington University physician-scientist Ziyad Al-Aly

In the ARC, activation of the JAK2/STAT3 pathway by leptin inhibits the activity of neurons expressing NPY and AgRP, which are orexigenic (appetite-stimulating)

Randomised controlled trials have also evaluated the long-term sequelae of exposure to this molecule in different study designs, increasing its importance as a tool for analyses of long-term metabolic processes

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While not GLP-1-specific, these platforms help identify dietary patterns that optimize medication response