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Liver is considered to be the primary site for the methylation of inorganic arsenic (iAs) and is shown to be critical specifically for the arsenic metabolism, and thus may be pharmacologically important as well

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miR-31 negatively regulates Foxp3 expression, either by binding to potential sites in the 3 UTR of Foxp3 mRNA [80] or by suppressing Gprc5a to inhibit the generation of peripheral Tregs (pTregs) [81]

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This biological process that reduces oxygen to water is not perfect but produces a significant amount of reactive oxygen species (ROS) such as the superoxide anion, hydrogen peroxide, and the hydroxyl radical (Balaban et al., 2005)

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