It follows that control of PER1 expression may potentially be employed to reduce tumor growth
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Our prior study infusing IGF-1 LR3 into normally grown late-gestation fetal sheep that resulted in increased fetal growth but decreased fetal insulin secretion used a dose of 6.6 gkg 1 h 1 based on an estimated fetal weight of 3.5 kg (final average LR3 dose 5.23 gkg 1 h 1 based on average actual fetal weight of 4.42 0.14 kg) (25)
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Many protocols specify administration on an empty stomach because elevated glucose can blunt the GH-release response in research models