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The Ser14 and Ser17 of Semaglutide form a network of hydrogen bonds involving the receptor residues Asn300, Arg299, and Thr298

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Time for returning to baseline LDL-C level might be slightly shorter using MEDI4166, around 10 and 14 days following a 1 mg/kg iv dose of MEDI4166 and anti-PCSK9 J16 mAb 42 respectively

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