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These studies do not establish safety, dosage, or effectiveness for human therapeutic use

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Although the virion DNA was found to be mostly unmethylated in both tissue culture and patient serum 16,17 , DNA methylation of the intranuclear HBV genome has been associated with repression of gene transcription in cultures 24,25,26

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doi:10.1016/j.diabres.2021.108899 Fathy MA, Anbaig A, Aljafil R, et al