Temporary fatigue: Some users experience mild fatigue during the first 3-5 days as their body adjusts
While this creates a daytime pulse and may boost morning energy and alertness, it doesn't leverage the robust nocturnal pulse and sleep-associated benefits of bedtime dosing
Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
guide explores this in more detail
A Note About Thyroid Concerns While early animal studies showed a potential increased risk of thyroid cancer, this hasnt been replicated in human studies
Wang L, Berger NA, Kaelber DC, Davis PB, Volkow ND, Xu R Incidence Rates and Clinical Outcomes of SARS-CoV-2 Infection With the Omicron and Delta Variants in Children Younger Than 5 Years in the US