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Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) have individually been shown to reduce cardiovascular and kidney outcomes in patients with T2DM, with a low hypoglycemia risk [3, 4]

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( D ) Mean relative PPP Flux in H441 cells treated with DMSO control or 1 M KEAPi (Davies et al, 2016) for 48 h and labeled with [1,2- 13 C]-glucose for 14.5 h