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When mast cells are activated in response to progesterone, the resulting histamine surge helps explain many of the hallmark features of APD, including: Hives (urticaria) caused by histamine-induced blood vessel dilation Intense itching (pruritus) driven by histamine signaling in the skin Angioedema , or deeper swelling beneath the skin and mucous membranes Asthma-like symptoms or shortness of breath , due to histamines effects on airway smooth muscle This mast cellhistamine connection also clarifies why treatments that target allergic pathways are often effective in APD, even though progesterone is a hormone rather than a classic allergen
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Dysbiosis, characterized by an imbalance of beneficial and harmful microbes, may contribute to inflammation, DNA damage, and tumorigenesis in the colon
When considering cost, factor in supplies (syringes, bacteriostatic water, alcohol swabs) and potential medical supervision fees
Moreover, the dietary intake or supplementary intake of L-arginine can increase and restore these nitric oxide levels and improve fertility, detoxification, brain power, and immune functions
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