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Short answer: raising circulating Lcarnitine is fast, but changing the carnitine content inside muscle fibers is slow and requires chronic dosing plus insulinmediated uptake
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These reactions are caused by the abrupt exposure of adaptations that have occurred in the nervous system in response to the chronic presence of the drug
Treatment usually starts at a low dose of 3.75 mg/23 mg for 14 days and then increases
It is not approved by the FDA for weight loss but can be prescribed off-label for weight loss, which makes it difficult to secure insurance coverage
