CagriSema combines semaglutide with cagrilintide (an amylin receptor agonist), targeting yet another hormone pathway involved in appetite regulation
Semaglutide is a long-acting GLP-1 receptor agonist with structural homology to native human GLP-1
Factors that may influence perioperative management include: Medication characteristics : Daily GLP-1 medications (liraglutide, oral semaglutide) have shorter durations of action than weekly formulations (injectable semaglutide, dulaglutide, exenatide extended-release) [3] Risk factors : Higher doses, recent dose increases, active gastrointestinal symptoms, or known gastroparesis may increase risk [1] [3] Procedure type : More complex surgeries or those requiring general anaesthesia may warrant different approaches than minor procedures Individual patient factors : BMI, presence of diabetes, and other medical conditions Some anaesthetists may recommend temporarily pausing GLP-1 therapy before certain procedures, particularly for patients with additional risk factors
Peptide therapy is generally well-tolerated when administered under professional supervision
Semaglutide for managing overweight and obesity (TA875) Chapter 1: Recommendations
Those who were overweight or obese and taking the drug to lose weight were seven times more at risk