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In the SURMOUNT-1 trial (N=2,539) of tirzepatide, GI adverse events led to treatment discontinuation in only 4.3-7.1% of participants across dose groups 21, suggesting that most side effects including those downstream of GI symptoms like cramping are manageable without stopping therapy

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Acknowledgments This study was supported by a postgraduate student research award from the Faculty of Science, University of Technology Sydney

The future of addiction treatment GLP-1 drugs are the first type of medication to show potential benefit across multiple substance types simultaneously