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Hyperglycemia and lipotoxicity drive sustained ROS production through NADPH oxidase (NOX4), mitochondrial respiratory chain complexes I and III, and xanthine oxidase, while concurrently depleting antioxidant defenses such as glutathione (GSH), superoxide dismutase (SOD2), and catalase

Topical treatment works directly on the affected area

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While still clinically meaningful, this represents about two-thirds of the weight loss achieved with injectable formulations at optimal doses