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5 Appetite, satiety, and behavioral peptide systems revisited Regulation of appetite and feeding behavior represents one of the most extensively investigated yet paradoxically undertranslated domains of peptide biology

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Significant reductions in HbA1c and fasting glucose were observed in adults with obesity type 2 diabetes, outperforming monotherapies

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Ocular Very common (10% or more): Diabetic retinopathy (up to 20.1%) Common (1% to 10%): Retinal disorders, diabetic retinopathy complications Uncommon (0.1% to 1%): Nonproliferative retinopathy Very rare (less than 0.01%): Nonarteritic anterior ischemic optic neuropathy (NAION) Diabetic retinopathy complications included need for retinal photocoagulation, need for treatment with intravitreal agents, vitreous hemorrhage, and onset of diabetes-related blindness

Frailty and the prediction of negative health outcomes: a meta-analysis