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When one drug inhibits CYP enzymes responsible for metabolising another CNS drug, plasma and brain concentrations may rise, increasing the risk of toxicity
Androgen metabolism via 17-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme
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Safety analyses were also conducted on all who received at least one dose of the trial medication
Participants taking the highest maintenance dose lost an average of 15 percent of their body weight by week 68, compared to 2.4 percent in the placebo group
