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The distinction most people miss: short-term tolerability is not the same as long-term safety

They work through different mechanisms, so the right one depends on your goal

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Vonoprazan Advantages Compared to Other PPIs There are some speculative arguments in favor of the application of vonoprazan instead of other PPIs as antisecretory drugs: (1) it is more potent in the inhibition of acid secretion, (2) it has a fast onset of action, (3) less antisecretory variation is reported, as well as (4) greater safety, and (5) better tolerability

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Collagen and Extracellular Matrix Synthesis The tripeptide stimulates fibroblast production of type I collagen, elastin, proteoglycans, and glycosaminoglycans