It was approved by FDA for type 2 diabetes (trade name: Mounjaro) in 2022, and for obesity (trade name: Zepbound) in 2023
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Some start with semaglutide given its lower price and excellent results, then switch to tirzepatide if they plateau or want to maximize outcomes
Obese individuals are known to suffer from heightened insulin resistance, which puts them at risk for type 2 diabetes, so these drugs are conducive to various improved health markers in these populations
Lancet 400(10366):18691881 Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S et al (2023) Retatrutide phase 2 obesity trial investigators
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