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Retatrutide Dosage in Published Research Doses reported in the published Phase 2 literature range from 1 mg to 12 mg administered subcutaneously once weekly in adult human cohorts, with the 12 mg arm producing the largest documented mean reduction in body weight
Separately, the TRANSCEND-T2D-1 trial part of a distinct diabetes programme rather than TRIUMPH reported an HbA1c reduction of up to 2.0 percentage points and 16.8 per cent weight loss at 40 weeks in 537 people with type 2 diabetes, and was published in The Lancet in June 2026
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