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Non-alcoholic fatty liver disease: Pathogenesis and clinical features NAFLD is the most common liver disease, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases (2)

We use the model to study the depletion of glutathione and the effect of the size and timing of N-acetyl-cysteine doses given as an antidote

Similarly, urate is also neuroprotective by enhancing GSH expression through activation of the Akt/GSK3/NRF2/GCLC pathway in mutant SOD1 G85R cellular and Drosophila models (Zhang et al., 2019b)

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However, experts in the area generally concur that a combination of data from multiple endpoints is needed to discriminate sensitizing and/or irritant substances in vitro

M.BoularandS.DepretsS.DuboisL.et al (2020)