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Rodriguez, PhD MPH Truveta, Inc, Bellevue, WA, Samuel Gratzl, PhD Truveta, Inc , Bellevue, WA, Charlotte Baker, DrPH MPH CPH Truveta, Inc , Bellevue, WA, Duy Do, PhD Truveta, Inc , Bellevue, WA, Nicholas Stucky, MD PhD Truveta, Inc , Bellevue, WA Increasing demand for GLP-1 RA medications has led to global shortages, which could result in patients switching to other medications, or discontinuing their treatment completely

For those denied GLP-1 coverage altogether, other oral alternatives like Qsymia and Contrave may be worth exploring

Second, several states expanded Medicaid coverage to include GLP-1s specifically approved for obesity, such as Wegovy and Zepbound

11,12 Notably, the potential neuroprotective properties of GLP-1 RAs extend to conditions like Alzheimer disease (AD) and Parkinson disease by ameliorating motor impairment and curtailing oxidative stress, inflammation, and apoptosis

The glucagon receptor component promotes lipid mobilization specifically from adipose tissue, which contributes to improved metabolic markers beyond what the scale shows

Methionine is important for Phase II detoxification (it supports the sulfation pathway) and helps with the absorption of two vital thyroid nutrients, selenium, and zinc