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The peak of nausea for most people falls in weeks six to eight, after which the bodys tolerance to the medication increases significantly
A 2019 meta-analysis by Wei et al 11 reviewed the results of 4 RCTs on the use of onabotulinumtoxinA for TN and noted a significant improvement in reported pain values in comparison with placebo, with an estimated number needed to treat of 1.9 to achieve a 50% reduction in pain intensity
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