The present study aims to investigate comparative dementia risk with initiators of GLP1 receptor agonists, SGLT2 inhibitors, or DPP4 inhibitors in people with type 2 diabetes aged 60 years, using real-world observational data from primary care practice records in the UK
Patients receive an individualized prescription, not a form-based dispensing
NanoBiT assays were carried out as previously described (28): 24 hours after transfection, cells were incubated in 3 mM glucose for a minimum of 2 hours, detached and resuspended in NanoGlo Live cell substrate (N2012, Promega), 1:20 dilution in HBSS, and seeded onto an opaque white 96-well half-area plate
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DJW reports serving on data monitoring committees for Novo Nordisk not related to the topic of this work
For intention-to-treat analysis, follow-up started at treatment assignment (T0) and ended at the occurrence of outcomes, death or last encounter (to 30 June 2024)
