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At first glance, this seems contradictory
However, during an initial loading phase, a more frequent schedule may be necessary
In mammals, GSH conjugates are often further metabolized by hydrolysis and N-acetylation, either in the gut or in the kidney, to give N-acetylcysteinyl conjugates known as mercapturic acids, which are excreted in the urine
References American Diabetes Association Professional Practice Committee
Further research to identify who may be most susceptible
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