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Combination approaches that pair GSH depletion with ferroptosis induction, immunotherapy, or chemotherapy may help overcome resistance, while standardized manufacturing and rigorous toxicity evaluation will be critical for regulatory approval

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The study was based only on data from the published literature, did not allow for prospective or randomized controlled trials, and did not explore the direct associations between drug penetration ratios and adverse fetal or neonatal outcomes

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As an additional control, growth inhibition assays were conducted on the antimalaria compounds artemisinin and chloroquine: the IC 50 values obtained (12 nM and 22 nM, respectively) are comparable to previously published results ( Supplementary Figure 6 )