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Mechanistic sub-study embedded in an efficacy trial + Incorporate GSM/dryness endpoints (validated questionnaires, clinician assessment, pH) into semaglutide RCTs or pragmatic trials, with pre-specified subgroup analyses by menopausal status and HRT use
Reduced Appetite: While beneficial for weight loss, some patients may find it difficult to eat enough nutrients
183 Indeed, research has shown that high salt conditions can inhibit tumor growth by enhancing antitumor immunity, particularly through the modulation of MDSC functions
& Olefsky, J
TZT improves endothelial dysfunction (ED) and associated inflammatory changes through modulation of glucose homeostasis, insulin sensitivity, and pro-inflammatory biomarkers release
Do not self-administer without professional direction
