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First, the evidence is limited to draw a definitive conclusion: only four small or moderate sized RCTs were included, and the risk of bias is generally moderate
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Whats Emerging in Practice Outside of Trials GLP-1s live in the wildprescribed broadly, dosed variably, and sometimes obtained without medical oversight
FPLC analysis revealed that plasma LDL-C in the HCD + ALC group exhibited a decreasing trend, whereas HDL-C showed an increasing trend (Figure 2D)
We also confirmed that the association of rs10305420 with GLP1 medication efficacy cannot be accounted for by T2D or smoking status (Supplementary Information and Supplementary Tables 7 and 8)
Looking forward to seeing how the safety profile holds up as we approach 2027
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