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doi: 10.1016/J.SURFIN.2021.101415 72 HillsR
Semaglutide lowers harmful LDL cholesterol and triglycerides
Perhaps theres more to these shifts than meets the eye
Mazdutide (Innovent's IBI362, licensed from Lilly), another GLP-1/glucagon dual, read out ~18.5% weight loss on its 9 mg arm in GLORY-2 - on par with semaglutide's 2.4 mg weekly ceiling, in a population with a ceiling for semaglutide of roughly 15%
In all these cases, the goal is to correct deficiency and prevent complications
In these areas, studies reported reduced activity of non-ETC mitochondrial enzymes, such as aconitase and pyruvate dehydrogenase
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