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doi: 10.1172/JCI67867 51 ZhangW.GaiC.DingD.WangF.LiW

These are averages, which means many individuals lose more and some lose less, depending on genetics, metabolic health, medication adherence, and lifestyle factors

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The Bottom Line Weight loss medications like semaglutide, tirzepatide, and phentermine can powerfully support your journey but the quality of your weight loss matters just as much as the quantity

Taking the pill with too much liquid or before fasting time is complete significantly reduces how much semaglutide reaches your bloodstream, which reduces its effectiveness

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