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(c) increased nitrosative stress as indicated by increased levels of nitric oxide (NO) metabolites and IgM directed to NO (nitroso) neoepitope adducts

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By contrast, a significant transient increase in RPF was noted on day 8 (96 (33276) ml/min/1.73 m 2 versus 77 (34271) ml/min/1.73 m 2 )