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Several studies (Table 3) have shown that LA significantly reduces body fat mass, hepatic clearance of TG-rich lipoproteins, and lipid droplets through upregulating the expression levels of hepatic lipolytic enzymes (ATGL, acyl-CoA thioesterase [Acot1], Acot2, Acsf2, and Crat) and downregulating the expression levels of liver lipogenic enzymes (patatin-like phospholipase domain protein [Pnpla3], Pnpla5, Elovl6, Acly, sn-glycerol-3-phosphate acyltransferase 1 [Gpat], Aacs, FASN, ACC, and SCD-1)

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ClinicalTrials.gov Identifier: NCT07437547

demonstrated a 29% higher drug uptake than non-targeted liposomes and a superior impact on disease delay when delivered by the intracerebroventricular route in ALS mice (124, 125)