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It typically begins with declining blood levels (stage I), followed by low cellular levels (stage II), increased homocysteine levels and reduced DNA synthesis (stage III), and finally macrocytic anemia (stage IV)

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On the other hand, based on studies performed in Sardinia, G6PD deficiency has some beneficial effect on longevity 20

Cushing's syndrome, though rare, causes weight gain through cortisol excess that weight loss injections cannot adequately address