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The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents

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AOD9604 alone significantly improved both gross morphological and histopathological cartilage scores versus saline controls, and the combination of AOD9604 with hyaluronic acid produced superior outcomes to either agent administered alone including significantly shorter lameness periods