References: Abenavoli L, Capasso R et al
The primary actions of GLP-1 include stimulating insulin secretion from pancreatic beta cells in response to elevated blood glucose (importantly, this insulin release is glucose-dependent, reducing hypoglycaemia risk), suppressing glucagon release (which prevents the liver from producing excess glucose), and slowing gastric emptying
Common side effects of retatrutide Retatrutide shares the same GI side effect profile as tirzepatide but at higher rates
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The abdominal profile continues to improve as residual swelling settles over the following months
However, it soon became clear that glucagon-like substances from the gut, as identified by Sutherland and de Duve [14], could interfere with the measurement of glucagon