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In some cases, patients may be sedated with benzodiazepines, or the antidote cyproheptadine may be used

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Advantage : Bioglutide Muscle Preservation# Bioglutide : Phase 2 data indicate body fat reduction without muscle loss, attributed to IGF-1 receptor activation

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Body composition substudy analyses using DXA scanning reveal the proportion of lean mass loss to total weight loss with Retatrutide treatment remains similar to other obesity pharmacotherapies, providing reassurance that enhanced weight loss does not translate to disproportionate muscle loss