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As a result of this difference, IGF-DES has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency of approximately 10-fold in vivo relative to IGF-1

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The mice with hyper-long telomeres exhibited reduced DNA damage with aging, improved metabolic markers such as lower LDL levels, improved glucose and insulin tolerance, decreased cancer incidence, and increased longevity (Muoz-Lorente et al., 2019)

Diabetes mellitus-related gut dysbiosis is linked to breakdown of the epithelial barrier and a reduction in short-chain fatty acids

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